Polyurethane is an elastomer polymer, which is flexible, tough and resistant. This material is widely used various fields such as automobile, aeroplane, textiles, construction industries. Currently there exists more than 1,000 manufacturing companies in Korea that are closely related to Polyurethane. In spite of a number of Polyurethane manufacturing companies, there are little attention in academia as well as industries to study the safety and manufacturing process improvement on Polyurethane. In this paper, we consider a case study for the Polyurethane manufacturer to improve productivity by using safety management and manufacturing process reengineering. After careful analysis, we derive three enhancements to increasing the safety and productivity for the target company. Especially, we achieve about 16% productivity improvement in roller manufacturing process by replacing manual stirring job with automated mixing machine.