Purpose: This study was to investigate the socio-demographic and health factors affecting on the health related quality of life (HRQoL) in elderly by gender. Methods: Data of the study were derived from the fifth Korean National Health and Nutrition Examination Survey (KNHANES V-2, 2011). The subjects were older adults aged 65 years or more (673 male and 925 female) and the number of the sample was 1,598. The authors analyzed the data with the SPSS/WIN 21.0 program. Results: For male, the affecting factors on the HRQoL were education level, monthly income, and number of chronic disease. For female, affecting factors on the HRQoL were depression, stress, and age. The activity limitation and subjective health showed statistically significant relationship with the HRQoL for both male and female. Conclusion: Health care providers should consider the gender difference when they plan to design program for the improvement of HRQoL for elderly in community.