Purpose: The purpose of the present study was to assess the effectiveness of a nursing skills enhancement program in improving the self-efficacy and self-esteem of senior nursing students. Methods: This was a nonequivalent control group pretest-posttest design study that enrolled 306 senior nursing students. The nursing students were randomly assigned to an experimental(n=132) or control group (n=174), and students assigned to the experimental group completed a nursing skills enhancement program, which consisted of four skills training components: IV infusion, enema, $O_2$ therapy by means of cannulation and urinary catheterization. Data were analyzed with frequency, the chi-squared test, and the paired t-test using the SPSS/pc 15.0 statistical program. Results: Our results showed that the self-esteem and self-efficacy of nursing students who were assigned to the nursing skills enhancement program were significantly better compared to those of nursing students in the control group (t=10.198 and t=6.452, for self-efficacy and self-esteem, respectively, p<.001 for both variables). Conclusion: Our findings clearly show that a nursing skills enhancement program is effective in improving the self-efficacy and self-esteem of senior nursing students.