In this research, we presented an effective clustering method based on ICA for the analysis of huge Raman hyperspectral dental data. The hyperspectral dataset captured by HR800 micro Raman spectrometer at UMKC-CRISP(University of Missouri-Kansas City Center for Research on Interfacial Structure and Properties), has 569 local points. Each point has 1,005 hyperspectal dentin data. We compared the clustering effectiveness and the clustering time for the case of using all dataset directly and the cases of using the scores after PCA and ICA. As the result of experiment, the cases of using the scores after PCA and ICA showed, not only more detailed internal dentin information in the aspect of medical analysis, but also about 7~19 times much shorter processing times for clustering. ICA based approach also presented better performance than that of PCA, in terms of the detailed internal information of dentin and the clustering time. Therefore, we could confirm the effectiveness of ICA for the analysis of Raman hyperspectral dental data.