In the context of the structural performance of an LNG hold, the mechanical characteristics of the insulation material are considered to be a critical design factor under cryogenic temperatures. This paper presents the thermal elasto-plastic behavior of the reinforced polyurethane foam (RPUF) adapted for the insulation material of a membrane-type LNG carrier via both experiments and numerical simulations realizing the cryogenic condition. The experiments are carried out to investigate the thermal transfer and thermal elasto-plastic deformation characteristics of an actual RPUF specimen. The heat transfer simulations based on the finite element method (FEM) include a forced convection analysis. The results of heat transfer analyses are compared with the experimental results. Reasonable cryogenic conditions for RPUF are reviewed based on both the analysis and experimental results.