In this study, silkgland powder of silkworm were investigated to see possibility for cosmetic powder materials. To test possibility as a baby powder cosmetics, total content rate of amino acids, DPPH free radical scavenging assay, MTT assay, and clinical trial were done. According to the result of the analysis of the amino acids of silkgland powder, serin (26.77%) content was the highest and asparatic acid (15.47%), and glycine (9.62%) were followed. DPPH free radical scavenging activity of silkgland powder was lower than vitamin C by 82.3% and 97%, respectively, which is relatively good. And the moisture and elasticity effect were increased in silkgland powder compared to control cosmetics by 210% and 185%, relatively. Thus, these results suggest that silkgland powder of silkworm may have beneficial properties as a material for cosmeceuticals.