This study examined the tribological characteristics of the drive shaft and axle system in vehicles. The first drive shaft example contained end play for a CV joint that transferred part of the transmission power to the wheel. The joint part of the drive shaft was deformed because of reduced durability due to wear. Thus, vibrations caused the body to shake and become unbalanced when the drive shaft transferred the power. The second example was the cross-section of a shaft that connected the slip-connection of the propeller shaft on the input side to the yoke flange of the output side; the durability was reduced because of corrosion. End play caused by wear between the bearing and cross-section shaft appeared to cause shaking. In the third example, a grease leak reduced lubrication and thus caused damage to the hub bearing and inside the knuckle. The failure was produced by sticking. The fourth example had noise produced by the gear and gear transfer. This was due to the backlash of the pinion and few ring gears for the differential gear. Therefore, drive shaft and axle systems must be thoroughly checked and managed to minimize and reduce failure phenomena.