When structural design of a tall building is conducted, reduction of wind-induced lateral displacement is one of the most important problem. For this purpose, additional dampers and vibration control devices are generally considered. In this process, control performance of additional devices are usually investigated for optimal design without variation of characteristics of a structure. In this study, multi-objective integrated optimization of structure-smart control device is conducted and possibility of reduction of structural resources of a tall building with additional smart damping device has been investigated. To this end, a 60-story diagrid building structure is used as an example structure and artificial wind loads are used for evaluation of wind-induced responses. An MR damper is added to the conventional TMD to develop a smart TMD. Because dynamic responses and the amount of structural material and additional smart damping devices are required to be reduced, a multi-objective genetic algorithm is employed in this study. After numerical simulation, various optimal designs that can satisfy control performance requirement can be obtained by appropriately reducing the amount of structural material and additional smart damping device.