In many technical fields including electronics and display manufacturing processes, properties of coating liquids could be greatly enhanced by adding nanopowders and it requires efficient mixing techniques to achieve uniform dispersion of nanoparticles in liquids. This paper presents the three-dimensional CFD simulations on the flowfields of a highly viscous liquid in the large scale industrial mixer of impeller type. The effects of several important design and operation parameters such as impeller geometry, rotational speed, and degree of liquid viscosity are investigated to appreciate the mixing performance by examining the computational results for flow pattern of rotationally stirred liquid of high viscosity in the mixer.