Energy consumption analysis of multi-family apartment is an important area of research for the design of energy-saving housing. In this study, we selected a universal type of Flat-type apartments and analyzed the heating energy consumption of variables such as U-value, G-value, infiltration rate, heating setpoint and boiler efficiency with EnergyPlus and eQUEST. With these results, we identify the characteristics of EnergyPlus and eQUEST and provided base data for the design of energy-saving housing. The results indicate that infiltration rate is the most important factors to consider. And eQUEST heating energy consumption is approximately 10% higher compared to the EnergyPlus under same condition.