The k-out-of-n system with mixed redundancy is defined as k-out-of-n system which both includes warm-standby and cold-standby components. In case that operating components in the system fail and the system needs quick transition of standby components to operation state, the k-out-of-n system with mixed redundancy is useful for decreasing system failure rate and operational cost. Reliability-Redundancy Optimization Problem (RROP) involves selection of components with multiple choices and redundancy levels for maximizing system reliability with constraints such as cost, weight, etc. A solution methodology by using harmony search algorithm for RROP of the k-out-of-n system with mixed redundancy to maximize system reliability was suggested in this study.