A comprehensive review on the technical standards about human factors (HF) design and software reliability maintenance for digital instrumentation and control (I&C) and human-machine interface technology (HMIT) in Japanese light water reactor nuclear power plants (NPPs) was given in this paper mainly by introducing the relevant activities at the Japan Electric Association to set up many industrial standards within the traditional framework of nuclear safety regulation in Japan. In Japan, the Fukushima Daiichi accident that occurred on March 11, 2011 has great impact on nuclear regulation and nuclear industries where concerns by the general public about safety have heightened significantly. However for the part of HF design and software reliability maintenance of digital I&C and HMIT for NPP, the author believes that the past practice of Japanese activities with the related technical standards can be successfully inherited in the future, by reinforcing the technical preparedness for the prevention and mitigation against any types of severe accident occurrence.