A valve is a marine structure that is subjected to multiple seawater loads. Therefore, it is necessary to define the kind of loads applied to it to confirm whether the structure has sufficient strength. In this research, we aimed to find the optimal solution for the stress and deformation of valves under various loads. We first selected design variables and implement a finite element analysis according to changes in the thickness of each component of a valve based on a central composite design. Next we developed a regression model of the response surface. Using this model, we calculated the optimal objective value based on NSGA-II. Finally, to confirm the correspondence between the optimal objective value and the real FEM value, we compared the optimal result and structural analysis result to verify the performance of NSGA-II.