This study was undertaken to investigate the degree of career satisfaction and its affecting factors for senior nursing students. The subjects were 131 senior nursing students from one college located in Seoul. The data analyzed by using SPSS-WIN 18.0 program. Career satisfaction showed a significant positive correlation with recognition of career related to major(r=.690, p<.001), learning preference related to major(r=.666, p<.001), participation of activities related to major(r=.537, p<.001), major performance(r=.231, p=.008), concentration of major(r=.508, p<.001), intrinsic motivation(r=.357, p<.001), problem solving ability(r=.452, p<.001), satisfaction of laboratorial practice(r=.476, p<.001) and satisfaction of clinical practice(r=.410, p<.001). In addition, recognition of career, learning preference, participation of activities, concentration of major, and satisfaction of laboratorial practice were significant predictors to explain career satisfaction(63%). It is necessary to develop an effective career guidance program to improve career satisfaction considering these findings.