The high temperature thermal attacks in welding can affect the residual stress of a frame for automotive assembly accompanying frame deformation. Also the residual stress can induce the negative effect on durability performance of the automobile. In order to analyze the frame deformation, the simplified test frame which had the similar shape (form) of the real automotive frame was fabricated. The contactless optical 3D scanner was used for the shape difference measurement of the frame between before and after the welding. The FE-model of the test frame was composed and the deformation and residual stress simulation were performed. The simulated results were compared with the measured results for the reference of the frame design following as the variation of welding sequency. The deformation shape of the frame by simulation was in good agreement with that by the experimental measurement. In addition, the optimized welding sequency with reduced deformation after welding could be achieved through these analyses.