In this study, to have a better judgment on the structural performance, the effects of dynamic Soil-Structure Interaction (SSI) on seismic behaviour and lateral structural response of mid-rise moment resisting building frames are studied using Finite Difference Method. Three types of mid-rise structures, including 5, 10, and 15 storey buildings are selected in conjunction with three soil types with the shear wave velocities less than 600m/s, representing soil classes $C_e$, $D_e$ and $E_e$, according to Australian Standard AS 1170.4. The above mentioned frames have been analysed under two different boundary conditions: (i) fixed-base (no soil-structure interaction), and (ii) flexible-base (considering soil-structure interaction). The results of the analyses in terms of structural lateral displacements and drifts for the above mentioned boundary conditions have been compared and discussed. It is concluded that the dynamic soil-structure interaction plays a considerable role in seismic behaviour of mid-rise building frames including substantial increase in the lateral deflections and inter-storey drifts and changing the performance level of the structures from life safe to near collapse or total collapse. Thus, considering soil-structure interaction effects in the seismic design of mid-rise moment resisting building frames, particularly when resting on soft soil deposit, is essential.