During the service life of a structure, design complications and unexpected events may induce unforeseen vibrations. These vibrations can be generated by malfunctioning machinery or machines that are modified or placed without considering the original structural design because of a change in the intended use of the structure. Significant vibrations occurred at a natural gas plant cooling structure during its operation due to cavitation effect within the hydraulic system. This study presents findings obtained from the in-situ vibration measurements and following finite-element analyses of the cooling structure. Comments are made on the updated performance level and damage state of the structure using the results of these measurements and corresponding numerical analyses. An attempt was also made to assess the applicability of traditional displacement-based vulnerability estimation methods in the health monitoring of structures under vibrations with a character different from those due to seismic excitations.