Since the beginning of the twentieth century, the progressive and rapid spread of reinforced concrete (RC) has led to the adoption of mixed masonry-RC solutions, such as the confined masonry. However, together with structures conceived with a definite role for earthquake behaviour, the spreading of RC technology has caused the birth of mixed solutions inspired more by functional aspects than by structural ones, such as: internal masonry walls replaced by RC frames, RC walls inserted to build staircases or raising made from RC frames. Usually, since these interventions rise from a spontaneous build-up, any capacity design or ductility concepts are neglected being designed only to bear vertical loads: thus, the vulnerability assessment of this class becomes crucial. To investigate the non-linear seismic response of these structures, suitable models and effective numerical tools are needed. Among the various modelling approaches proposed in the literature and codes, the authors focus their attention on the equivalent frame model. After a brief description of the adopted model and its numerical validation, the authors aim to point out some specific peculiarities of the seismic response of mixed masonry-RC structures and their repercussions on safety verification procedures (referring in particular way to the non-linear static ones). In particular, the results of non-linear static analyses performed parametrically to various configurations representative of different interventions are discussed.