PURPOSE: This study determined the effect of balance control therapy in the brain activation. METHODS: Twenty-two college students who showed decrease of muscle strength in O-ring test were as participants in this study. And the subjects were randomly divided into experimental group (n=13) and control group (n=9). Measurement device is portable EEG (Nihonkhoden, Japan). Examinations used twenty electrodes attached to the head to capture electrical brain signals during 5 minutes with brain activated states such as the awaked state and the data were compared between the two groups. RESULTS: After treatment by balance control therapy, P3 (p<.025) and P4 areas (p<.025) showed a significantly lower ST index in the experimental group than the control group, The variation of ST index in P4 area (p<.025) was decreased in the experimental group but was increased in the control group. CONCLUSION: These results showed that the balance control therapy was helpful to change the brain activation such as the stress (ST) index at the sensory area in the college students.