Research on decreasing the weight of composite sandwich panels is in progress. This paper reports the experimental results for the mechanical behavior of a composite sandwich panel. The skins of sandwich panels were made of glass fiber sheets and plywood matrix composites. Their interior layers consisted of glass fiber pultrusion pipes and gold foam. Experimental tests were performed to obtain the mechanical properties and complex mechanical behavior. Before fatigue tests, tensile tests and 3-point bending tests were carried out to obtain the optimal design and determine their strength and failure mechanisms in the flat-wise position. After the static test, a fatigue test were conducted at a load frequency of 5 Hz, stress ratio (R) of 0.1, and endurance limit for the S-N curve. It showed that the failure modes were related to both the core design and skin failure.