Carboxymethyl cellulose (CMC) is a cellulose derivative having water-soluble property, biodegradability, and biocompatibility. It has been used in various medical applications as forms of gel, film, membrane, or powder. In this study, composite CMC nonwovens were produced, by a wet-laid nonwoven process, to improve the wet strength of carboxymethyl cellulose nonwovens. Followed by preparing the CMC fibers from cotton fiber, the composite CMC nonwovens composed of CMC fibers and PE/PP bicomponent fibers were manufactured by using 85/15 % v/v of ethanol/water solution as a dispersion medium. Structural analyses of CMC fibers, such as XRD, TGA, FT-IR, and degree of substitution indicated that CMC fibers were successfully produced. The wet strength of CMC nonwoven was dramatically increased by blending with the PE/PP fibers without sacrificing the key properties for wound dressing materials such as liquid absorption, gel blocking and liquid retention. It is expected that the composite CMC nonwovens will be a good candidate for wound dressing materials for mild exudate condition.