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서지반출
Enhanced solubility and permeability of exemestane solid dispersion powders for improved oral delivery
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  • Enhanced solubility and permeability of exemestane solid dispersion powders for improved oral delivery
  • Enhanced solubility and permeability of exemestane solid dispersion powders for improved oral delivery
저자명
Eedara. Basanth Babu,Kankane. Mradul,Jukanti. Raju,Nagabandi. Vijay Kumar,Bandari. Suresh
간행물명
Journal of pharmaceutical investigation
권/호정보
2013년|43권 3호|pp.229-242 (14 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The aim of the present investigation was to enhance the solubility of exemestane (EXM), by solid dispersion (SD) technique using PEG 6000 as a carrier. Phase solubility studies were conducted with PEG 6000 and PEG 20000 to evaluate the effect of carriers on aqueous solubility of EXM. The aqueous solubility of EXM was favoured with PEG 6000 compared to PEG 20000. SDs of EXM using polyethylene glycol 6000 (PEG 6000) as carrier were prepared in different drug to carrier ratios. Solid-state characterization indicated decrease in crystallinity of the drug. The in vitro dissolution rate of EXM was enhanced from both SDs and tablet formulations prepared using SD compared to pure EXM. The in situ permeability studies investigated using single-pass intestinal perfusion technique in rats revealed increase in effective intestinal permeability ($P_{eff}$, cm/s) by 4.45 folds with SDs. Thus, EXM-PEG 6000 SDs showed improved solubility and permeability.