Polyester/polypropylene (PP) and polyester/micro-modal (PMM) fabrics with double structures were prepared by subtracting loops on the skin side and face side, respectively. The moisture management properties of the PP and PMM fabrics were characterized using a moisture management tester (MMT), after which the properties were compared with those of cotton. Results showed that PP has better moisture management properties and faster distribution properties as compared with those of cotton. PP can easily transfer sweat from the skin side to the surface side to keep the skin side dry. By contrast, the moisture content remains high on the skin side of PMM as compared with cotton. The moisture content and transepidermal water loss (TEWL) during the short-term test periods were analyzed using PMM, after which the results were compared with those of cotton. After applying lotion in the PMM fabric, its TEWL significantly improved (P<0.05). Base on the results of the MMT and TEWL tests, PP could be used in summer to remove irritants and sweat. PMM can be used in winter to improve skin barrier functions.