Myanmar(Burma) has been preserved valuable environmental resources because of its political isolation. But recently, Myanmar has moved a capital city(Naypyidaw) at central forest area and it has been urbanized radically since 2005. In this paper, we built multi-temporal land cover map from Landsat images of 1970s to 2012 with ENVI 4.5 software. For a broad approach, administrative district Yamethin which includes Naypyidaw is classified into 3 classes and with only Naypyidaw region is classified with 4-5 classes to analyse specific changes. And with forest cover extracted by Object Oriented Classification, we evaluated forest fragmentation before and after the development using Patch Analyst(FRAGSTATs 3.3) at Yamethin area. For Yamethin area, there were significant forest cover change, 51% in 1999 to 48% in 2012, and for Naypyidaw area, 67% in 1999 to 57% in 2012 respectively. Also landscape indices resulted from Patch Analyst concluded that the total edge, edge density and mean shaped index of forest patches increased and total core area is decreased. It is attributed from land cover change with urbanization and agricultural land expansion.