With the environmental changes of the times, consumers expect new experiences and seek hotels with various leisure facilities and sensuous design rather than existing static and conservative ones. In particular, boutique hotels connected to all the aspects of lifestyle including architecture, culture, art and fashion are trying out a variety of designs through collaborations in the ways of enhancing their brand images in the design industry. Design through collaboration between different fields has an infinite possibility of breaking from classicism and creating a new type of space in hotel design. Thus, this study attempts to analyze a few cases of boutique hotels by collaborative design that has recently been vitalized and to seek for a direction by suggesting the methods of utilizing design by collaboration for the hotel industry that will further be expanded in the future. For this purpose, first, the theories of collaboration and boutique hotel will be reviewed and the characteristics will be drawn out based on the examples of boutique hotels to which collaborations have been applied by enterprises and designers. By analyzing and classifying the cases of the domestic and foreign boutique hotels through practical experiences among the hotels recently designed by the collaborations between enterprises and designers based on the basic frame of the five characteristics drawn out: identity, symbolism, temporality, locality and interaction, objective values will be drawn out and data for presenting the future orientation will be built. In the Korean hotel industry that is gradually expanding, boutique hotel designs through the appropriate collaboration between enterprises and designers should be considered for the extensive development of the future hotel industry.