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Evaluation of comparative cytotoxicity of spray-type chemicals used in household products
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  • Evaluation of comparative cytotoxicity of spray-type chemicals used in household products
  • Evaluation of comparative cytotoxicity of spray-type chemicals used in household products
저자명
Kwon. Jung-Taek,Seo. Gyun-Baek,Kim. Hyun-Mi,Shim. Ilseob,Lee. Byoungcheun,Jung. Ji-Youn,Kim. Pilje,Choi. Kyunghee
간행물명
Molecular & cellular toxicology
권/호정보
2013년|9권 1호|pp.51-56 (6 pages)
발행정보
대한독성유전단백체학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Chemicals are widely used in our daily lives for various purposes such as disinfectant, air fresher, paints and hair spray. However, their pulmonary toxicity has less studied compared with oral and dermal toxicity. Therefore, the purpose of this study was to examine comparative cytotoxicity of triclosan (TCS), benzisothiazolinone (BIT), dichlorophene (DCP) and citral (CTR) major using spray-type chemicals used in household products (CHPs) in Korea. TCS, DCP and BIT induced more severe mitochondria injury and cell membrane damage than CTR in lung epithelial cell during 24 hrs exposure. Furthermore, the result of clonogenic assay revealed that exposure of CHPs significantly decreased colony size and that BIT reduced cell growth at most compared with TCS, DCP and CTR. In summary, results of comparative cytotoxicity demonstrated that inhalation of TCS, DCP and BIT may cause pulmonary toxicity. Therefore, our results suggest that TCS, BIT and DCP are requiring inhalation toxicity assessment for maintaining a high quality of life.