This study investigates the structural analysis result with vibration and fatigue on 3 kinds of bicycle saddle models. When the static load applies on the upper plane of model, maximum stress becomes within the allowable stress in case of model 1. As the value of Stress or deformation becomes lower on the order of model types 1, 2 and 3, these models become more stabilized or safer at durability in this order. On the vibration analysis, model type 1 has the maximum stress or deformation more than 5 times by comparing with model type 1 or 2. Model type 1 becomes most excellent on vibration durability. As maximum displacement due to vibration happens in case of model type 3, it becomes unstabilized. But the stresses of model types 1, 2 and 3 become within the allowable stress and these models are considered to be safe. At the status of the severest fatigue load, model type 3 becomes safer than model type 1 or 2. This study result is applied with the design of safe bicycle saddle and it can be useful to improve the durability by predicting prevention against the deformation due to its vibration and fatigue.