In this paper, the payload condition is considered and computer simulation is carried out to analyze the dynamic behavior of the middle-sized truck under the condition with different weight and location. The computer model for the truck is established and ADAMS/Car is employed to simulate the truck vehicle. A single lane change and bump-pass simulation are performed to evaluate the performance according to the weight and the position of it. Effects of the location and weight of commercial vehicle are analyzed. According to the simulation results, the front deck is preferred as the load location.