This paper proposes a RFID cell planning scheme for indoor location-awareness. We theoretically develop four objective functions that yield objective goals significant to the optimal design of a RFID cell topology and simulation is conducted to evaluate the performance of the proposed RFID cell planning scheme. We also evaluate the performance of the proposed technique after practically installing RFID readers in an indoor space to configure a RFID cell topology. Performance evaluations are conducted in terms of the following objective goals: minimal number of RFID readers for configuring a RFID cell topology, maximal RFID cell coverage areas for indoor location-awareness, minimal overlapping cells, and maximal indoor location-awareness accuracy.