Multiplexers based on isolation circuits made of metamaterial lines are proposed and studied. The new approach provides unique advantageous features beneficial to system designer. For instance, there is no need to modify the filters used in multiplexers. Also, the design process is straightforward. In this paper, two types of multiplexers based on metamaterial isolation circuits are presented, and their operation concepts are explained. Also, theories and design process of isolation circuits are presented to help readers design and fabricate proposed multiplexers. For verifying the concepts, two types of triplexers and two types of quadruplexers are designed and fabricated. All filters used in the multiplexers are commercial surface acoustic wave filters. The measured results are well matched with the simulation results.