This paper presents a new method for analyzing the maximum efficiency of a wireless power transfer (WPT) system with multiple n resonators. The method is based on ABCD matrices and allows transformation of the WPT system with multiple n resonators into a single two-port network system. The general maximum efficiency equation of a WPT system with multiple n resonators is derived using the ABCD matrix. Use of this equation allows placement of the relay resonators for maximum efficiency even though they are asymmetrical. The general maximum efficiency equation and the method of the optimum placement are verified by a full wave simulation. The results show that the method is useful for the analysis of a WPT system with relay resonators.