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Antifungal Synergy of Theaflavin and Epicatechin Combinations Against Candida albicans
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  • Antifungal Synergy of Theaflavin and Epicatechin Combinations Against Candida albicans
  • Antifungal Synergy of Theaflavin and Epicatechin Combinations Against Candida albicans
저자명
Betts. Jonathan W.,Wareham. David W.,Haswell. Stephen J.,Kelly. Stephen M.
간행물명
Journal of microbiology and biotechnology
권/호정보
2013년|23권 9호|pp.1322-1326 (5 pages)
발행정보
한국미생물생명공학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

New antifungal agents are required to compensate for the increase in resistance to standard antifungal agents of Candida albicans, which is an important opportunistic fungal pathogen that causes minor infections in many individuals but very serious infections in those who are immune-compromised. In this study, combinations of theaflavin and epicatechin are investigated as potential antifungal agents and also to establish whether antifungal synergy exists between these two readily accessible and cost-effective polyphenols isolated from black and green tea. The results of disc diffusion assays showed stronger antibacterial activity of theaflavin:epicatechin combinations against C. albicans NCTC 3255 and NCTC 3179, than that of theaflavin alone. Minimum inhibitory concentrations (MICs) of 1,024 ${mu}g/ml$ with theaflavin and 128-256 ${mu}g/ml$ with theaflavin:epicatechin combinations were found. The fractional inhibitory concentration indexes were calculated, and the synergy between theaflavin and epicatechin against both isolates of C. albicans was confirmed. Theaflavin:epicatechin combinations show real potential for future use as a treatment for infections caused by C. albicans.