Margin of safety against potential of progressive collapse is among important features of a structural system. Often eccentricity in plan of a building causes concentration of damage, thus adversely affects its progressive collapse safety margin. In this paper the progressive collapse of symmetric and asymmetric 3-story reinforced concrete ordinary moment resisting frame buildings subjected to the earthquake ground motions are studied. The asymmetric buildings have 5%, 15% and 25% mass eccentricity. The distribution of the damage and spread of the collapse is investigated using nonlinear time history analyses. Results show that potential of the progressive collapse at both stiff and flexible edges of the buildings increases with increase in the level of asymmetry in buildings. It is also demonstrated that "drift" as a more easily available global response parameter is a good measure of the potential of progressive collapse rather than much difficult-to-calculate local response parameter of "number of collapse plastic hinges".