This paper investigates earthquake response of reinforced concrete regular frames subjected to rebar corrosion. A typical four-story reinforced concrete frame is designed according to Turkish Earthquake Code in order to examine earthquake response. Then different levels of rebar corrosion scenarios are applied to this frame structure. The deteriorated conditions as a result of these scenarios are included loss in cross sectional area of rebar, loss of mechanical properties of rebar, loss in bond strength and variations in damage limits of concrete sections. The frame is evaluated using a nonlinear static analysis in its sound as well as deteriorated conditions. The rebar corrosion effect on the structural response is investigated by comparing the response of the frame in each scenario with respect to the sound condition of the frame. The results shows that the progressive deterioration of the frame over time cause serious reductions on the base shear and top displacement capacity and also structural ductility of the corroded frames. The propagation time, intensity, and extensity of rebar corrosion on the frame are important parameters governing the effect of rebar corrosion on earthquake response of the frame.