The purpose of this study was to identify factors affecting stress and adaptation in newborn congenital heart disease patients of parents. Data were obtained through questionnaires from 181 newborn congenital heart disease inpatients of parents from P university in Y city. The data were analyzed SPSS 18.0, using descriptive statistics, Pearson correlation coefficients and stepwise multiple regression. Stress was negative correlated with level of patents adaptation. Social support, marital communication and family cohesion were positive correlated with level of patents adaptation. The explained variances for patents adaptation were 45.2% and factors affecting patients adaptation were congenital heart disease, family cohesion, stress, social support and marital communication. Educational intervention program for parents of newborn with congenital heart disease, reduce stress, and to increase the adaptation will be developed.