We investigate an approximate analytic expression of signal distortion caused by the interaction between self-phase modulation (SPM) and dispersion in the dispersion-managed optical transmission where the dispersion is optimally compensated. From the analytic study, we obtain the analytic expression of the signal distortion in dispersion-managed optical transmission system. To confirm the validity of the analytic expression, we show that the eye-opening penalties calculated by the analytic expression correspond with the simulation results. Using the analytic result, we can easily estimate the signal distortion without complex nonlinear simulations.