This paper deals with the multi-objective optimization of tire reinforcement structures such as the tread belt and the carcass path. The multi-objective functions are defined in terms of the discrete-type design variables and approximated by artificial neutral network, and the sensitivity analyses of these functions are replaced with the iterative genetic evolution. The multi-objective optimization algorithm introduced in this paper is not only highly CPU-time-efficient but it can also be applicable to other multi-objective optimization problems in which the objective function, the design variables and the constraints are not continuous but discrete. Through the illustrative numerical experiments, the fiber-reinforced tire belt structure is optimally tailored. The proposed multi-objective optimization algorithm is not limited to the tire reinforcement structure, but it can be applicable to the generalized multi-objective structural optimization problems in various engineering applications.