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Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice
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  • Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice
  • Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice
저자명
Lee. Hyun-Ah,Song. Yeong-Ok,Jang. Mi-Soon,Han. Ji-Sook
간행물명
Preventive nutrition and food science
권/호정보
2013년|18권 3호|pp.163-168 (6 pages)
발행정보
한국식품영양과학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In this study, we investigated the inhibitory effects of Baechu kimchi added Ecklonia cava on the activities of ${alpha}$-glucosidase and ${alpha}$-amylase and its alleviating effect on the postprandial hyperglycemia in STZ-induced diabetic mice. Baechu kimchi added Ecklonia cava (BKE, 15%) was fermented at $5^{circ}C$ for 28 days. Optimum ripened BKE was used in this study as it showedthe strongest inhibitory activities on ${alpha}$-glucosidase and ${alpha}$-amylaseby fermentation time among the BKEs in our previous study. The BKE was extracted with 80% methanol and the extract solution was concentrated, and then used in this study. The BKE extract showed higher inhibitory activities than Baechu kimchi extract against ${alpha}$-glucosidase and ${alpha}$-amylase. The $IC_{50}$ values of the BKE extract against ${alpha}$-glucosidase and ${alpha}$-amylase were 0.58 and 0.35 mg/mL, respectively; BKE exhibited a lower ${alpha}$-glucosidase inhibitory activity but a higher ${alpha}$-amylase inhibitory activity than those of acarbose. The BKE extract alleviated postprandial hyperglycemia caused by starch loading in normal and streptozotocin- induced diabetic mice. Furthermore, the BKE extract significantly lowered the incremental area under the curve in both normal and diabetic mice (P<0.05). These results indicated that the BKE extract may delay carbohydrate digestion and thus glucose absorption.