This paper deals with the development of expressions relating structural seismic response parameters to the epicentral distances of an earthquake and the natural period of several reinforced concrete buildings (6, 9 and 12 storey), with three floor plans: symmetric, monosymmetric, and unsymmetric. These structures are subjected to seismic spectrum of accelerations collected during the Boumerdes earthquake (Algeria, May $21^{st}$, 2003, Mw=6.8) at different epicentral distances. The objective of this study is to develop relations between structural responses namely: base shear, storey displacements, interstory drifts and epicentral distance and fundamental period for a given earthquake. The seismic response of the buildings is carried out in both longitudinal transverse and directions by the response spectrum method (modal spectral approach).