Using of masonry infill as partitions, in flat slab frame buildings is a common practice in many parts of the world. The infill is, generally, not considered in the design and the buildings are designed as bare frames. More of fundamental information in the effect of masomary infill on the seismic performance of RC building frames is in great demand for structural engineers. Therefore the main aim of this research is to evaluate the seismic performance of such buildings without (bare frame) and with various systems of the masonary infill. For this purpose, thirteen three dimensional models are chosen and analyzed by SAP2000 program. In this study the stress strain relation model proposed by Crisafulli for the hysteric behaviour of masonary subjected to cyclic loading is used. The results show that the nonstructural masonary infill can impart significant increase global strength and stiffness of such building frames and can enhance the seismic behaviour of flat slab frame building to large extent depending on infill wall system. As a result great deal of insight has been obtained on seismic response of such flat slab buildings which enable the structural engineer to determine the optimum position of infill wall between the columns.