Objectives : The aim of this study is to assess change of the skin and quality of life of the Pustulosis Palmaris et Plantari patient by Traditional Korean Medicine. Methods : We used Bihaesamsp-tanggagambang and herbal medication for external use. The progress is evaluated by Dermatology Life Quality Index (DLQI), and the patient gave marks about the subjective symptoms from 0 to 4. Results : Through the treatment, Dermatology Life Quality Index (DLQI) changed from 29 to 22, and subjective symptoms of both itching and burning sensation changed from 4 to 1. Conclusions : Traditional Korean Medicine seems to be effective for the Pustulosis Palmaris et Plantari treatment. More clinical cases and studies are needed to develop an organized therapeutic measures.