In this paper, an analysis on exergy efficiency of high-efficiency R717 OTEC power system for the efficiency and pressure drop in main components were investigated theoretically in order to optimize the design for the operating parameters of this system. The operating parameters considered in this study include turbine and pump efficiency, and pressure drop in a condenser and evaporator, respectively. As the turbine efficiency of R717 OTEC power system increases, the exergy efficiency of this system increases. But pressure drop in the evaporator of R717 OTEC power system increases, the exergy efficiency of this system decreases, respectively. And, in case of exergy efficiency of this OTEC system, the turbine efficiency and pressure drop in a condenser on R717 OTEC power system is the largest and the lowest among operation parameters, respectively.