This research was done to evaluate the potential for destruction of perchlorate in municipal sewage. Laboratory experiments were conducted in flasks containing 3 liters of raw sewage. Sewage was mixed with defined amount of perchlorate and various additives. Perchlorate reduction in sewage did occur, but was quite variable, ranging from 0 to 72% over 72 hour. Addition of even a small amount of perchlorate acclimated biomass (167 mg/L SS) significantly reduced the lag and resulted in complete perchlorate removal. Perchlorate reduction in sewage-brine mixtures was inhibited when the dissolved oxygen level was greater than 2 mg/L, and when the mixture salinity was relatively high (conductivity = 14 mS with equivalent TDS = 8 g/L). When nitrate ($NO_3{^-}$) was present with perchlorate in the laboratory flask tests of sewage-brine mixtures, nitrate reduction proceeded first. A significant amount of nitrite ($NO_2{^-}$) accumulated in the sewage-brine mixtures, accounting for about 66% of initial nitrate nitrogen ($NO_3$-N).