An empirical study on railway controller and railway engineer who work in a domestic railway corporation was undertaken to verify the effects of emotional burnout and empowerment and organizational commitment on cooperation and safety behavior. The results of the analysis confirmed that the relations between emotional burnout, empowerment and organizational commitment as well as the relations between cooperation and safety behavior had negative effects. In contrast, the results of the analysis confirmed that empowerment and organizational commitment had positive effects on safety behavior and cooperation, and were effective because of all interactions among emotional burnout, safety behavior and cooperation. In conclusion this study convincingly demonstrates that emotional control, empowerment and organizational commitment of controller and engineer are important factors to secure safe operation of trains based on high safety behavior and cooperation behavior.