The design of the exhaust manifold for the pulse converters of a 4 strokes high power medium-speed diesel engine is presented in terms of fatigue analysis. The said system undergoes thermal expansion due to high temperature of exhaust gas and is exposed to intrinsic vibration of the internal combustion engine. Moreover, the exhaust pulse generates pressure pulsating along the runner inside manifold. Under such circumstances, the design and construction of exhaust manifold must be carried out in a way to prevent early failure due to fracture. To validate the design concept, a test rig was developed to simulate the combination of thermal and vibrational movements, simultaneously. Experimental results showed that a certain sense of reliability can be achieved by considering a field factor obtained from the results of engine bench tests.