We propose a new development for calculating a computer-generated hologram (CGH) through the use of multiple general-purpose graphics processing units (GPGPUs). For optimization of the implementation, CGH parallelization, object point tiling, memory selection for object point, hologram tiling, CGMA (compute to global memory access) ratio by block size, and memory mapping were considered. The proposed CGH was equipped with a digital holographic video system consisting of a camera system for capturing images (object points) and CPU/GPGPU software (S/W) for various image processing activities. The proposed system can generate about 37 full HD holograms per second using about 6K object points.