This study was conducted to identify the relation between sense of coherence and academic stress in nursing students. Data were collected from 248 nursing students using self-report questionnaire. Data were analyzed by SPSS WIN18.0. There was a significant correlation between sense of coherence and academic stress. Major satisfaction, friends relationship and comprehensibility as a subcategory of sense of coherence accounted for 31.3% of the variance in academic stress. In conclusion, these results indicate that we should search strategies for improvement of teaching method to heighten the major satisfaction, enforcement of sense of coherence, and development of counseling program to reduce academic stress among nursing students.