An iterative hybrid structural dynamic reliability prediction model has been developed under multiple-time interval loads with and without consideration of stochastic structural strength degradation. Firstly, multiple-time interval loads have been substituted by the equivalent interval load. The equivalent interval load and structural strength are assumed as random variables. For structural reliability problem with random and interval variables, the interval variables can be converted to uniformly distributed random variables. Secondly, structural reliability with interval and stochastic variables is computed iteratively using the first order second moment method according to the stress-strength interference theory. Finally, the proposed method is verified by three examples which show that the method is practicable, rational and gives accurate prediction.