This study was investigated in optimum condition of pulping of ramie and the mechanical properties of non-woven fabric for the performance of ramie/cotton panty liner. The result of pulping condition on ramie was most suitable for type I (mixed NaOH with $Na_2CO_3$ in 30%:70%). The sample (I) was showed yield value of 68.2% and the best fibrillation and lignin removal rate. The non-woven fabrics of ramie/cotton were made in range of ramie content of 0, 15 and 30%. As ramie content increased, so were increased in air permeability, compressive strength and compression recovery rate. But surface roughness and compressional energy were decreased. Therefore, the non-woven fabrics of ramie/cotton are very suitable in hygienic goods for female panty liner. The ramie panty liner showed a little decrease in absorption and strength, as increasing the amount of ramie. But the performance of ramie panty liner was appeared beyond standard values used by usual panty liner.