In this paper, suitable working fluid of 1MW Organic Rankine Cycle(ORC) with liquid-vapor ejector using effluent from power plant is selected. The results of comparison performance of 5 refrigerants are as follows; R600a, R134a, R1270, R236fa, R235fa. The operating parameters considered in this study include the condensation capacity evaporation capacity and efficiency. As a result of comparison of basic ORC system and with liquid-vapor ejector, with ORC system presents the higher system efficiency since the ejector makes the turbine outlet pressure lower than condensation pressure through its pressure recovery. Also, this ejector ORC system is advantageous in miniaturizing the size of components owing to decrease of evaporation capacity and condensation capacity.